Higher Degree by Research Application Portal

(+)-Lysergic Acid Diethylamide, (+)-LSD is a classical and potent hallucinogen, used recreationally since 1938; banned in 1968 in the US and other countries; and now a molecule of interest for treatment of mental health disorders. It is considered non-addictive with a low potential for abuse, and has been evaluated in numerous controlled studies, resulting in beneficial behavioral changes. This project will involve preparing structural analogues of LSD. Working with Woke Pharmaceuticals these analogues  will be examined for psychedelic and neuroplasticity-promoting actions and if they can be used as a treatment for disorders such as anxiety, PTSD, and substance abuse. In the early stages of this project the binding and activating the serotonin 2A (5-HT2A, agonist) receptor in the brain will be investigated.

The successful applicant will have a strong background in practical and theory in synthetic and/or medicinal chemistry.

Applicants need to hold a masters degree or first class honours degree in chemistry.

Strong background in practical and theory in synthetic and/or medicinal chemistry.

By email to A/Prof Scott G Stewart (scott.stewart@uwa.edu.au).

A/Prof Scott Stewart