Higher Degree by Research Application Portal

TitleThe synthesis of LSD analogues for anxiety, PTSD and substance abuse
CourseDoctor of Philosophy

(+)-Lysergic Acid Diethylamide, (+)-LSD is a classical and potent hallucinogen, used recreationally since 1938; banned in 1968 in the US and other countries; and now a molecule of interest for treatment of mental health disorders. It is considered non-addictive with a low potential for abuse, and has been evaluated in numerous controlled studies, resulting in beneficial behavioral changes. This project will involve preparing structural analogues of LSD. Working with Woke Pharmaceuticals these analogues  will be examined for psychedelic and neuroplasticity-promoting actions and if they can be used as a treatment for disorders such as anxiety, PTSD, and substance abuse. In the early stages of this project the binding and activating the serotonin 2A (5-HT2A, agonist) receptor in the brain will be investigated.

KeywordsSynthetic Chemistry
Medicinal Chemistry
Organic Chemistry
LSD analogues
CategoriesSynthetic Chemistry
Opportunity statusOpen
Open date16 Oct 2023
Close date31 Dec 2024
Research areaChemical Sciences

The successful applicant will have a strong background in practical and theory in synthetic and/or medicinal chemistry.

Applicants need to hold a masters degree or first class honours degree in chemistry.

Citizenship statusDomestic
Enrolment statusFuture student
Current student
Specific requirement

Strong background in practical and theory in synthetic and/or medicinal chemistry.

How to apply

By email to A/Prof Scott G Stewart (scott.stewart@uwa.edu.au).


A/Prof Scott Stewart

Scholarship details
Scholarship typeStipend scholarship
Scholarship valueAUD $35,000 per annum
SchoolSchool of Molecular Sciences
Course typeDoctorates