Higher Degree by Research Application Portal
| Title | Brian Metcalf PhD Project in Biological Chemistry: Exploring Redox Cofactors' Synergy |
|---|---|
| Supervisor | Dr Marie Migaud |
| Course | Doctor of Philosophy |
| Keywords | synthetic organic chemistry, cell biology, redox cofactors |
| Categories | studentship |
| Research area | Chemical Sciences |
| Project description | The project will entail the development of innovative synthetic methodologies to access masked and unmasked isotopically labelled nucleosides and nucleotides, precursors of redox cofactors. Once synthetized, these entities will be used on primary and immortalised endothelial cells, in the first instance, to probe the synergy between biosynthetically independent redox cofactors. This project intends to reveal new pathogenic pathways of chronic kidney disease progression. In addition to developing skills in advanced nucleotide synthetic chemistry, the candidate will harness extensive expertise in complex analytical chemistry, and water-soluble compound purification. This will complemented with the acquisition of fundamental expertise in cell biology and cell-based assay development. |
| Opportunity status | Open |
| Open date | 31 Aug 2026 |
| Close date | 31 Oct 2026 |
| Funding source | Brian Metcalf Endowed Chair Studentship |
| School | Graduate Research School |
| Contact | Professor Marie Migaud, Brian Metcalf Chair in Biological Chemistry marie.migaud@uwa.edu.au |
| Specific project requirement | An undergraduate degree in chemistry or related field is required. |
| Course type | Doctorates |
| Description | The Doctor of Philosophy (PhD) is a program of independent, supervised research that is assessed solely on the basis of a thesis, sometimes including a creative work component, that is examined externally. The work presented for a PhD must be a substantial and original contribution to scholarship, demonstrating mastery of the subject of interest as well as an advance in that field of knowledge. Visit the course webpage for full details of this course including admission requirements, course rules and the relevant CRICOS code/s. |
| Duration | 4 years |
Guidance
Biological Chemistry; Nucleotide synthesis; Cell Biology.
If you wish to obtain more information on the project, contact Professor Migaud via email (marie.migaud@uwa.edu.au). Be specific as to what you wish to learn about the project. For more information about the Migaud lab's past research and contribution to science at the interface between Chemistry and Biology and Biomedical Research, consult google scholar.
If interested in joining the Migaud group to work on this project and are ready to take on the challenge of becoming a PhD candidate in the School of Molecular Sciences, send your CV and a cover letter to Professor Migaud via email (marie.migaud@uaw.edu.au).
How to apply for this opportunity: https://researchdegrees.uwa.edu.au