Higher Degree by Research Application Portal

TitleThe accuracy of the ROTEM coagulation analyser to support coagulation management in the perioperative period. The influence of thresholds on accuracy and utility
SupervisorA/Pro Matthew Linden
Clp Neville Gibbs
Prof Wendy Erber
CourseDoctor of Philosophy
Keywordsthromboelastography, haemostasis, coagulation, perioperative bleeding, transfusion, major surgery, anaesthesia, fibrinogen
CategoriesHaemostasis
Research areaHealth Sciences
Project description

This project seeks to address knowledge gaps related to the utility of viscoelastic testing in coagulopathy of major surgery in relation to;

  • The diagnostic accuracy of ROTEM to identify hypofibrinogenaemia, thrombocytopaenia and clotting factor deficiency in a large cohorts of patients undergoing either cardiac or non-cardiac surgery, given that most previous studies have been in small cohorts.
  • The optimal ROTEM thresholds to minimise both false negatives and false positives for the identification of hypofibrinogenaemia in cardiac and non-cardiac surgery
  • The diagnostic accuracy of ROTEM to identify hypofibrinogenaemia, thrombocytopaenia and clotting factor deficiency particularly in end stage liver disease and liver malignancy undergoing liver transplant surgery
  • The diagnostic accuracy of ROTEM to identify hypofibrinogenaemia, thrombocytopaenia and clotting factor deficiency particularly in a large cohort of patients experiencing obstetric related haemorrhage
  • The effect of FIBTEM amplitude (surrogate measure of fibrinogen concentration) on the diagnostic accuracy of non-fibrinogen coagulation assessment using ROTEM
  • Patient, pathology and surgical related factors that might contribute to the inaccuracy in ROTEM assessment of coagulopathy 
Opportunity statusOpen
Open date27 Jun 2025
Funding source

Department of Anaesthesia, Sir Charles Gairdner Hospital

SchoolGraduate Research School
Contact

A/Prof Matthew Linden

Ph: +618 6457 2739

matthew.linden@uwa.edu.au

Specific project requirement

This project suites a consultant anaesthetist clinician researcher with experience in a cardiovascular and liver transplant setting. The candidate should have a minimum of 15 hours of non-clinical time per week dedicated to undertake the research

Course typeDoctorates
Description

The Doctor of Philosophy (PhD) is a program of independent, supervised research that is assessed solely on the basis of a thesis, sometimes including a creative work component, that is examined externally. The work presented for a PhD must be a substantial and original contribution to scholarship, demonstrating mastery of the subject of interest as well as an advance in that field of knowledge. 

Visit the course webpage for full details of this course including admission requirements, course rules and the relevant CRICOS code/s.

Duration4 years

Guidance

This project suites a consultant anaesthetist clinician researcher with experience in a cardiovascular and liver transplant setting. The candidate should have a minimum of 15 hours of non-clinical time per week dedicated to undertake the research.

Enquire here